Hanke, L.*, Sheward, D. J.*, Pankow, A., Vidakovics, L. P., Karl, V., Kim, C., Urgard, E., Smith, N. L., Astorga-Wells, J., Ekström, S., Coquet, J. M., McInerney, G. M., Murrell, B. Multivariate mining of an alpaca immune repertoire identifies potent cross-neutralizing SARS-CoV-2 nanobodies. Science Advances, (2022). LINK
Hanke, L.*, Das, H. *, Sheward, D. J., Perez Vidakovics, L., Urgard, E., Moliner-Morro, A., Kim, C., Karl, V., Pankow, A., Smith, N. L., Porebski, B., Fernandez-Capetillo, O., Sezgin, E., Pedersen, G. K., Coquet, J. M., Hällberg, B. M., Murrell, B., McInerney, G. M. A bispecific monomeric nanobody induces spike trimer dimers and neutralizes SARS-CoV-2 in vivo. Nature Communications 13, (2022). LINK
Moliner-Morro, A., McInerney, G. M. > Hanke, L. Nanobodies in the limelight: Multifunctional tools in the fight against viruses. Journal of General Virology 103, (2022). LINK
Moliner‐Morro, A., Sheward, D. J., Karl, V., Vidakovics, L. P., Murrell, B., McInerney, G. M., Hanke, L. Picomolar SARS‐CoV‐2 neutralization using multi‐arm PEG nanobody constructs. Biomolecules 10, 1–11 (2020). LINK
Hanke, L., Vidakovics Perez, L., Sheward, D. J., Das, H., Schulte, T., Moliner-Morro, A., Corcoran, M., Achour, A., Karlsson Hedestam, G. B., Hällberg, B. M., Murrell, B., McInerney, G. M. An alpaca nanobody neutralizes SARS-CoV-2 by blocking receptor interaction. Nature Communications 11, 4420 (2020). LINK
Hanke, L., Schmidt, F. I., Knockenhauer, K. E., Morin, B., Whelan, S. P., Schwartz, T. U., Ploegh, H. L. Vesicular stomatitis virus N protein‐specific single‐domain antibody fragments inhibit replication. EMBO reports 18, e201643764 (2017). LINK
Hanke, L., Knockenhauer, K. E., Brewer, R. C., Diest, E. van, Schmidt, F. I., Schwartz, T. U., Ploegh, H. L. The Antiviral Mechanism of an Influenza A Virus Nucleoprotein- Specific Single-Domain Antibody Fragment. mBio 7, 1–11 (2016). LINK
Schmidt, F. I., Hanke, L., Morin, B., Brewer, R., Brusic, V., Whelan, S. P. J. J., Ploegh, H. L. Phenotypic lentivirus screens to identify functional single domain antibodies. Nature Microbiology 1, 16080 (2016). LINK
*equal contribution
For a full publication list see Google Scholar
Leo Hanke, PhD
Principal Investigator
Carl Johan Hagströmer
Postdoctoral Researcher
Mirte Pascha
Postdoctoral Researcher
Avadhoot Jadhav
PhD student
William Purba
Master student
Thunder
Alpaca
Contact:
The Hanke Lab is located in the 7th floor of the BioClinicum building (J7:20), Karolinska Institutet.
We are part of the Anna Färnert group in the
Division of Infectious Diseases and the Department of Medicine, Solna.
Visiting address:
NKS BioClinicum, J7:20
Solnavägen 30 / Akademiska ståket 1
171 64 Solna
Email: leo.hanke@ki.se